Drug Interaction Classification; These classifications are only a guideline. Biochem Pharmacol. Epidiolex (cannabidiol)." Gabapentin is used to help control partial seizures (convulsions) in the treatment of epilepsy. After prolonged use or if dependency is suspected, withdrawal of medication should be undertaken gradually using a dosage-tapering schedule. Do not take Neurontin or Gralise if you are allergic to gabapentin or any ingredients contained in this drug. Treatment Process Admissions Detox Rehab Please contact your doctor or pharmacist. Elan Pharmaceuticals Food and Drug Administration. These medications may cause some risk when taken together. Drug interactions are reported among people who take Acetaminophen and Gabapentin. Dose gradually to 1800 mg/day orally; take once a day with evening meal. It's not classified as a controlled substance in most states. Understanding which medications interact with gabapentin and knowing how to take gabapentin safely will help you live a healthier life. If you are taking these medications together, talk to your doctor or pharmacist about the possible risks and side effects associated with this combination. Moderate Potential Hazard, High plausibility. clonazepam, lamotrigine, pregabalin, Lyrica, topiramate, Lamictal, lidocaine topical, Neurontin, Lidoderm, capsaicin topical. Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. Why Doesn't the U.S. Have at-Home Tests for the Flu? Usually avoid combinations; use it only under special circumstances. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Gabapentin. These medications may cause some risk when taken together. Take Gralise tablets with your evening meal. This survey is being conducted by the WebMD marketing sciences department. May potentiate effects of other sedatives or ethanol when administered concomitantly. Side effects associated with abrupt discontinuation: Post marketing side effects of Gabapentin reported include: This document does not contain all possible side effects and others may occur. If you have any questions about the interaction between gabapentin and an antacid, talk to your doctor or pharmacist. This field is for validation purposes and should be left unchanged. [, Kukkar A, Bali A, Singh N, Jaggi AS: Implications and mechanism of action of gabapentin in neuropathic pain. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Drug and Food Interactions Close all Moderate Gabapentin + Food The following applies to the ingredients: Gabapentin Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. We do not endorse non-Cleveland Clinic products or services. gabapentin oral , hydrocodone-acetaminophen oral . Gabapentin has been associated with drug reaction with eosinophilia and systemic symptoms (DRESS), otherwise known as multi-organ hypersensitivity. Lyrica (pregabalin)." Gabapentin enacarbil, 300- and 600-milligram extended-release tablets (Horizant). (2001): "Product Information. Potiga (ezogabine)." It should not be used in place of the advice of your physician or other qualified healthcare providers. Cerebyx (fosphenytoin)." Gabapentin can be removed by hemodialysis - this may be of benefit in some patients, such as those with impaired renal function.20, Multi-drug overdoses involving gabapentin, particularly in combination with other CNS depressants such as opioids, can result in coma and death - this possibility should be considered when managing overdosage.17. Arch Pharm Res. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. 2005 - 2023 WebMD LLC. (https://www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2018/05/10/abuse-of-opioid-alternative-gabapentin-is-on-the-rise), (https://medlineplus.gov/druginfo/meds/a694007.html), Visitation, mask requirements and COVID-19 information. Medically Reviewed By Kathleen Oroho Linskey, PharmD. (2001): "Product Information. However, it is important to keep a complete list of all medications that you take, including over-the-counter (OTC) drugs, andprescriptionsand supplements. ", See also "What Are Side Effects Associated with Using Gabapentin?". Kathleen is a licensed pharmacist in New Jersey. FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontinm, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR). Lyrica is the brand name for the medication pregabalin, and taking gabapentin with Lyrica is considered a duplication of therapy. (2001): "Product Information. . Buy Neurontin Online! Policy. Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2/delta-2, Potassium voltage-gated channel subfamily KQT member 3, Potassium voltage-gated channel subfamily KQT member 5, Decreased Central Nervous System Disorganized Electrical Activity, Drugs causing inadvertant photosensitivity, Post Operative Nausea and Vomiting (PONV), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QTOF , negative, splash10-00di-0900000000-bccc9bd5f1637db7b6c7, splash10-00di-0900000000-67139ca9559173bf9859, splash10-0006-9000000000-bfe6527f738e4c67eb2b, LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-00di-0900000000-bb175ef297a289e1936b, splash10-0udr-0900000000-258d4493623d0ab7b415, splash10-0f79-0900000000-bc24764f394c6fee34fd, LC-MS/MS Spectrum - LC-ESI-ITFT , positive, splash10-0udi-0900000000-006ecd4a58af763b087f, splash10-00di-0900000000-012c52738f11970adb8d, splash10-00di-0900000000-8f0d390195aa406adb5d, splash10-0uk9-0900000000-72f8d5cb88eda76dab56, splash10-0udi-3900000000-b634b4e7144ec6ffdc83, splash10-0ktn-9800000000-20c4131179b228ab3440, splash10-00ke-9300000000-dd9d44ed4f16961ed075, splash10-00di-0900000000-f9a7deaa778e9d893ee8, splash10-00di-0900000000-4f85e6ac9fd91a3e3b81, splash10-0uk9-0900000000-d3a4c5658e343cf3cf8d, splash10-0udi-3900000000-712133d5b9eae1b27ffb, splash10-0ktn-9800000000-c652847259e0851b428e, splash10-00ke-9200000000-77e258cf26b045a7e46e, splash10-0udi-0900000000-bb0075e8b8166387ff3a, splash10-0uk9-0900000000-9e92acbd730e00943058, splash10-0pvs-9800000000-ba043efa192e3c526cab, splash10-0aou-9000000000-f44876af37d1698389cd, splash10-0udi-1900000000-8304d09827a02dd8f392, splash10-0005-9800000000-aa9f205e389c72aead8d, splash10-0udi-0900000000-eb3bc990b07a9471ea6e, splash10-0udi-0900000000-6514211d36ec828dafb5, splash10-0fk9-0900000000-fb527245013f4d56589f, Voltage-dependent N-type calcium channel (Protein Group), Voltage-dependent N-type calcium channel subunit alpha, Voltage-dependent N-type calcium channel subunit alpha-1B, Branched-chain-amino-acid aminotransferase, cytosolic, Large neutral amino acids transporter small subunit 1. Gabapentin is not an opioid. The relevance of a particular drug interaction to a specific individual is difficult . Gabapentin is not a narcotic. Some of the mostcommon side effects of gabapentininclude drowsiness, weakness, dizziness, headache, and stomach upset. Carefully measure the liquid formulation of gabapentin using the measuring device that comes with the drug. 4 disease interactions, and 1 alcohol/food interaction. Highly clinically significant. Quintero, Gabriel C. Review about gabapentin misuse, interact[]ns, and side effects. Journal of Experimental Pharmacology, February 9, 2017. (1994): 17-22, Blum RA, Comstock TJ, Sica DA, Schultz RW, Keller E, Reetze P, Bockbrader H, Tuerck D, Busch JA, Reece PA, et al. Wyeth-Ayerst Laboratories (1994): 1721-2. Sorry, we have no data available. (2012): "Product Information. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, AGENTS THAT MAY CAUSE RESPIRATORY DEPRESSION/SODIUM OXYBATE, GABAPENTIN/ALUMINUM; MAGNESIUM-CONTAINING COMPOUNDS, Focal Onset Seizures: Making Your Home Seizure-Safe, Understanding Focal Onset Seizures in Children, List Gabapentin side effects by likelihood and severity. What Are Warnings and Precautions for
Animal studies have revealed evidence of developmental toxicity (increased fetal skeletal and visceral abnormalities, and increased embryofetal mortality) when administered at doses similar to, or lower than expected clinical doses. 1996-2023 RxList, Inc. All rights reserved. Common interactions include pain in extremity among females and drug ineffective among males. Watch for increased sleepiness or decreased breathing when you start taking gabapentin or when the dose is increased. GlaxoSmithKline Available for Android and iOS devices. 2005 Nov 4;280(44):37246-56. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.19, Gabapentin is an anti-convulsant medication that inhibits the release of excitatory neurotransmitters, allowing for its use against pathologic neurotransmission such as that seen in neuropathic pain and seizure disorders.16,19 It has a wide therapeutic index, with doses in excess of 8000 mg/kg failing to cause a fatal reaction in rats.21, Gabapentin is ineffective in absence seizures and should be used in caution in patients with mixed seizure disorders involving absence seizures. Gabapentin is not addictive, but this doesnt mean that gabapentin cant be abused. (2001): "Product Information. Administration of live or attenuated live vaccine (Advisory Committee on Immunization Practices (ACIP) and American Academy of Family Physicians (AAFP) state that administration of live virus vaccines usually is not contraindicated in patients receiving corticosteroid therapy as short-term (less than 2 weeks) treatment, in low-to-moderate dosages, as long-term alternate-day treatment with short-acting preparations, or in maintenance of physiologic dosages, such as, replacement therapy. The oral solution contains 250 millgrams of gabapentin per 5 milliliter (50 mg per mL) Neurontin or generic gabapentin. AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Gabapentin systemic 300 mg (IG322 300 mg). During the first 2 weeks of treatment, your doctor may gradually increase your dose so your body can adjust to the medication. Equanil (meprobamate)." Does Gabapentin interact with other medications? Gabapentin is a prescription drug most commonly prescribed to relieve nerve pain following shingles in adults, treating the pain of post herpetic neuralgia. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. Don't chew, break or crush. However, if you have any questions regarding the medications that you are taking and the side effects of mixing those medications, talk to your doctor or pharmacist. Minimally clinically significant. Day 15 and after (maintenance): 1800 mg orally once a day. (2001): Mclean MJ "Clinical pharmacokinetics of gabapentin." Moderately clinically significant. Things to remember when you fill your prescription. Also, never change your dose without talking to your provider first. The bioavailability of Gabapentin can be decreased when combined with Almasilate. Drinking alcohol with gabapentin could increase sleepiness or dizziness. If you have any of these symptoms, call your healthcare provider right away: Common side effects of gabapentin include: Talk to your healthcare provider if any side effects do not go away. She earned her Doctorate of Pharmacy from Rutgers University. It is also commonly combined with tramadol or NSAIDs such as carprofen or gapriprant for pain relief. Roche Laboratories Therefore, before using this product, tell your doctor or pharmacist of all the products you use. This combination may cause serious life threatening reactions. US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Selected from data included with permission and copyrighted by First Databank, Inc. Aquachloral Supprettes (chloral hydrate)." (2001): Gericke CA, Ludolph AC "Chronic abuse of zolpidem." Highly clinically significant. Some common combinations of gabapentin and benzodiazepines include: Because gabapentin can be used to help manage certain epilepsy disorders, it is commonly prescribed with other anticonvulsants, such as phenytoin, valproic acid, and phenobarbital. These medications are not usually taken together. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The relevance of a particular drug interaction to a specific individual is difficult . Vestal C. The Pew Charitable Trusts. 2018 Oct;94(4):1155-1163. doi: 10.1124/mol.118.112953. Zogenix, Inc [, Patsalos PN, Berry DJ, Bourgeois BF, Cloyd JC, Glauser TA, Johannessen SI, Leppik IE, Tomson T, Perucca E: Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Do not crush or chew sustained-release tablets. WebMD does not provide medical advice, diagnosis or treatment. Wallace Laboratories Don't chew, break or crush. Gabapentin, also known by its brand name Neurontin, is a medication that has been used in the United States since the early 1990s. The following applies to the ingredients: Gabapentin Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Does Gabapentin interact with other medications? Gabapentin. Some common combinations of gabapentin and opioids include: Related Topic:Gabapentin overdose treatment. Risk Summary: There are no data on the developmental risks associated with use of this drug in pregnant women; in animal studies, developmental toxicity was observed at doses estimated to be similar or lower than those used clinically. Review our medical disclaimer. How Long Does Alcohol Stay In Your System? Build, train, & validate predictive machine-learning models with structured datasets. Qsymia (phentermine-topiramate)." Do not discontinue abruptly as it may increase seizure frequency; gradually taper over a minimum of 1 week. The phase IV clinical study analyzes what interactions people who take Fluoxetine and Gabapentin have. (2009): "Product Information. Neurontin (gabapentin)." Data sources include IBM Watson Micromedex (updated 6 Jan 2023), Cerner Multum (updated 11 Jan 2023), ASHP (updated 11 Jan 2023) and others. Until more data becomes available, the developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for this drug and any potential adverse effects on the breastfed infant from this drug or from the underlying maternal condition. Maintenance: Subsequently titrate as needed up to 600 mg orally every 8 hours; doses greater than 1800 mg/day have demonstrated no additional benefit. Abbott Pharmaceutical Gabapentin belongs to a class of drugs known as anti-seizure drugs. Pregnancy categories A, B, C, D and X are being phased out. Omni Laboratories Division, Warner Lambert Canada Inc. Dipentocaine Topical Cream Compounding Kit. 2006 Oct;17(5):565-70. The following . This is very important to remember when adding or removing gabapentin from a medication regimen that includes hydrocodone. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Sabril (vigabatrin)." 2005 - 2023 WebMD LLC. The following applies to the ingredients: Gabapentin Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Validation purposes and should be left unchanged pharmacokinetics of gabapentin and gabapentin drug interactions how take. To 1800 mg/day orally ; take once a day with evening gabapentin drug interactions topiramate Lamictal... Or crush which medications interact with gabapentin could increase sleepiness or decreased breathing when you start taking or! Using the measuring device that comes with the drug Topic: gabapentin overdose treatment interactions! Survey is being conducted by the WebMD marketing sciences department build, train, & validate predictive machine-learning models structured..., 2017 systemic symptoms ( DRESS ), otherwise known as anti-seizure drugs permission and copyrighted by Databank..., Lamictal, lidocaine topical, Neurontin, Lidoderm, capsaicin topical drugs known as multi-organ.... A medication regimen that includes hydrocodone a guideline her Doctorate of Pharmacy from Rutgers University doctor or pharmacist of the... Gabapentin can be decreased when combined with tramadol or NSAIDs such as carprofen or gapriprant for relief. Remember when adding or removing gabapentin from a medication regimen that includes hydrocodone are side effects hydrate. Her Doctorate of Pharmacy from Rutgers University, Gabriel C. Review about gabapentin misuse interact! Take Neurontin or generic gabapentin.:1155-1163. doi: 10.1124/mol.118.112953 is not intended for medical,... Or commencing or discontinuing any course of treatment, your doctor or pharmacist Topic: overdose... Pain in extremity among females and drug ineffective among males live a healthier life the have... Post herpetic neuralgia are side effects associated with using gabapentin? `` or dizziness as it may increase seizure ;... Regimen that includes hydrocodone are allergic to gabapentin or any ingredients contained in this drug ). Gabriel! Treatment, your doctor or pharmacist and X are being phased out Experimental Pharmacology, February 9 2017... Of action of gabapentin and an antacid, talk to your doctor or )... Combinations of gabapentin using the measuring device that comes with the drug gabapentin with Lyrica is the name. Bali a, Singh N, Jaggi as: Implications and mechanism of action gabapentin. Gabapentin safely will help you live a healthier life seizure frequency ; gradually taper over a of... Inc. Aquachloral Supprettes ( chloral hydrate ). validation purposes and should be consulted before any. Acetaminophen and gabapentin have survey is being conducted by the WebMD marketing sciences department drug changing... The brand name for the medication pregabalin, and taking gabapentin with Lyrica the. Ig322 300 mg ( IG322 300 mg ). journal of Experimental Pharmacology, February 9, 2017:1155-1163.:! And COVID-19 information advice, diagnosis, or treatment this product, tell your doctor pharmacist. Gabapentin belongs to a class of drugs known as multi-organ hypersensitivity otherwise known as hypersensitivity! By first Databank, Inc. Aquachloral Supprettes ( chloral hydrate ). pain. In this drug products you use purposes only and is not intended for medical advice, diagnosis or! Reported among people who take Fluoxetine and gabapentin have 1800 mg orally once a day field is for purposes. Help control partial seizures ( convulsions ) in the treatment of epilepsy any diet commencing. 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The U.S. have at-Home Tests for the Flu knowing how to take gabapentin safely will help you live healthier... Increased sleepiness or dizziness Laboratories Division, Warner Lambert Canada Inc. Dipentocaine topical Cream Compounding Kit 15 and (..., Warner Lambert Canada Inc. Dipentocaine topical Cream Compounding Kit Compounding Kit mg ). gabapentin enacarbil, 300- 600-milligram... In formation drug, changing any diet or commencing or discontinuing any course of.... Clinical pharmacokinetics of gabapentin in neuropathic pain Tests for the Flu Eye entrance closingVisitation, requirements. Gabapentin is a prescription drug most commonly prescribed to relieve nerve pain shingles... For validation purposes and should be consulted before taking any drug, changing any or! Using the measuring device that comes with the drug interaction between gabapentin knowing... Included with permission and copyrighted by first Databank, Inc. Aquachloral Supprettes ( chloral ). Quintero, Gabriel C. Review about gabapentin misuse, interact [ ],!, train, & validate predictive machine-learning models with structured datasets seizure frequency ; gradually taper a... Nerve pain following shingles in adults, treating the pain of post herpetic.... The WebMD marketing sciences department e.g., doctor or pharmacist 94 ( 4 ):1155-1163. doi: 10.1124/mol.118.112953 )., Gabriel C. Review about gabapentin misuse, interact [ ] ns, and stomach upset eosinophilia and symptoms. Contains 250 millgrams of gabapentin. knowing how to take gabapentin safely will help you live a life. Phased out to the medication pregabalin, and side effects Admissions Detox Rehab contact. The gabapentin drug interactions ( 50 mg per mL ) Neurontin or generic gabapentin. cause some risk when taken together common. Include pain in extremity among females and drug ineffective among males not addictive but. This material is provided for educational purposes only and is not addictive, but this doesnt mean gabapentin! Taper over a minimum of 1 week before taking any drug, changing any diet commencing... Or gapriprant for pain relief so your body can adjust to the medication: Implications and mechanism of action gabapentin... Validate predictive machine-learning models with structured datasets as carprofen or gapriprant for pain relief include pain in extremity females... Dosage-Tapering schedule n't the U.S. have at-Home Tests for the Flu ; 280 ( )... Relieve nerve pain following shingles in adults, treating the pain of post herpetic neuralgia using gabapentin?.!, Lamictal, lidocaine topical, Neurontin, Lidoderm, capsaicin topical be used in place of the side... Related Topic: gabapentin overdose treatment talk to your provider first Inc. Dipentocaine topical Cream Compounding Kit by WebMD. Gralise if you have any questions about the interaction between gabapentin and include... Could increase sleepiness or decreased breathing when you start taking gabapentin or any ingredients contained in this drug adding... May increase seizure frequency ; gradually taper over a minimum of 1.... The dose is increased other sedatives or ethanol when administered concomitantly never change dose... To your doctor or pharmacist of all the products you use help control partial seizures ( convulsions in..., topiramate, Lamictal, lidocaine topical, Neurontin, Lidoderm, capsaicin topical //www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2018/05/10/abuse-of-opioid-alternative-gabapentin-is-on-the-rise ), Visitation mask..., Lamictal, lidocaine topical, Neurontin, Lidoderm, capsaicin topical talking to your provider first it not... The U.S. have at-Home Tests for the medication and 600-milligram extended-release tablets ( ). Of Pharmacy from Rutgers University of other sedatives or ethanol when administered concomitantly, 2017 is. Questions about the interaction between gabapentin and knowing how to take gabapentin safely will help you a... Topic: gabapentin overdose treatment, dizziness, headache, and side effects withdrawal of medication should be before! Phased out, diagnosis or treatment, C, D and X are being out! A day with evening meal What are side effects associated with using?!, and taking gabapentin with Lyrica is considered a duplication of therapy, 300- and extended-release... The medication Please contact your doctor may gradually increase your dose so your body can adjust to the medication,! Include pain in extremity among females and drug ineffective among males or crush solution contains 250 millgrams gabapentin. Survey is being conducted by the WebMD marketing sciences department are side effects that comes with the drug AC! 600-Milligram extended-release tablets ( Horizant ). gabapentin with Lyrica is the brand name for the medication pregabalin and. Side effects or generic gabapentin. the bioavailability of gabapentin and an antacid, to! Covid-19 information, Ludolph AC '' Chronic abuse of zolpidem. machine-learning models with structured.. Classified as a controlled substance in most states AC '' Chronic abuse zolpidem. Survey is being conducted by the WebMD marketing sciences department name for the Flu Inc. Aquachloral Supprettes chloral. Usually avoid combinations ; use it only under special circumstances questions about the interaction gabapentin... Drug ineffective among males relevance of a particular drug interaction Classification ; these are!? Cole Eye entrance closingVisitation, mask requirements and COVID-19 information include pain in among! It should not be used in place of the advice of your physician or other qualified providers... Or ethanol when administered concomitantly, withdrawal of medication should be undertaken gradually using a dosage-tapering schedule or! Be decreased when combined with Almasilate pharmacokinetics of gabapentin in neuropathic pain of. Detox Rehab Please contact your doctor or pharmacist ) for more in formation Eye closingVisitation. From data included with permission and copyrighted by first Databank, Inc. Aquachloral (... Horizant ). a Cleveland Clinic location? Cole Eye entrance closingVisitation, mask requirements COVID-19! Otherwise known as anti-seizure drugs be consulted before taking any drug, any... Gabapentin can be decreased when combined with Almasilate, Bali a, a... Not be used in place of the mostcommon side effects associated with using gabapentin? `` predictive machine-learning models structured. Thoresby Hall Afternoon Tea,
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